ARG42458

anti-CD268 / BAFF R antibody [11C1]

anti-CD268 / BAFF R antibody [11C1] for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,IHC-Frozen sections and Human

Overview

Product Description Mouse Monoclonal antibody [11C1] recognizes CD268 / BAFF R
Tested Reactivity Hu
Tested Application FACS, IHC-Fr, IHC-P
Specificity The mouse monoclonal antibody 11C1 recognizes an extracellular epitope of CD268 / BAFF R (B cell-activating factor receptor), a 19 kDa type III transmembrane protein expressed on resting B cells and CD4-positive T cells, but down regulated after activation.
Host Mouse
Clonality Monoclonal
Clone 11C1
Isotype IgG1, kappa
Target Name CD268 / BAFF R
Antigen Species Human
Immunogen Human CD268-transfected murine L1.2 cells.
Conjugation Un-conjugated
Alternate Names CD antigen CD268; BROMIX; BAFF-R; CD268; Tumor necrosis factor receptor superfamily member 13C; BAFF receptor; BAFFR; B-cell-activating factor receptor; prolixin; CVID4; BLyS receptor 3

Application Instructions

Application Suggestion
Tested Application Dilution
FACS1 - 4 µg/ml
IHC-FrAssay-dependent
IHC-PAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purification with Protein A.
Buffer PBS and 15 mM Sodium azide.
Preservative 15 mM Sodium azide
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 115650 Human TNFRSF13C

Swiss-port # Q96RJ3 Human Tumor necrosis factor receptor superfamily member 13C

Gene Symbol TNFRSF13C
Gene Full Name tumor necrosis factor receptor superfamily, member 13C
Background B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]
Function B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. [UniProt]
Cellular Localization Membrane; Single-pass type III membrane protein. [UniProt]
Calculated MW 19 kDa