ARG42322
anti-CD273 / PD-L2 antibody [24F.10C12] (APC)
anti-CD273 / PD-L2 antibody [24F.10C12] (APC) for Flow cytometry and Human
Overview
Product Description | APC-conjugated Mouse Monoclonal antibody [24F.10C12] recognizes CD273 / PD-L2 |
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Tested Reactivity | Hu |
Tested Application | FACS |
Specificity | The mouse monoclonal antibody 24F.10C12 recognizes an extracellular epitope of CD273 / PD-L2 (also known as B7-DC), a 25 kDa type I transmembrane protein expressed by dendritic cells, activated monocytes and T cells, heart, first trimester placenta, lung and liver, as well as in Hodgkin´s lymphoma cells and primary mediastinal B cell lymphoma (PMBL). |
Host | Mouse |
Clonality | Monoclonal |
Clone | 24F.10C12 |
Isotype | IgG2a, kappa |
Target Name | CD273 / PD-L2 |
Antigen Species | Human |
Immunogen | Human CD273. |
Conjugation | APC |
Alternate Names | B7DC; bA574F11.2; PDL2; CD antigen CD273; PD-L2; Programmed cell death 1 ligand 2; CD273; Btdc; PDCD1L2; Programmed death ligand 2; Butyrophilin B7-DC; B7-DC; PD-1 ligand 2; PDCD1 ligand 2 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification | Purified |
Buffer | PBS and 15 mM Sodium azide. |
Preservative | 15 mM Sodium azide |
Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | PDCD1LG2 |
Gene Full Name | programmed cell death 1 ligand 2 |
Function | Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity). [UniProt] |
Cellular Localization | Isoform 3: Secreted. Isoform 2: Endomembrane system; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. [UniProt] |
Calculated MW | 31 kDa |