ARG58076
anti-CD278 / ICOS antibody
anti-CD278 / ICOS antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections,ICC/IF and Human,Mouse,Rat
Overview
Product Description | Rabbit Polyclonal antibody recognizes CD278 / ICOS |
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Tested Reactivity | Hu, Ms, Rat |
Tested Application | ICC/IF, IHC-P, WB |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | CD278 / ICOS |
Antigen Species | Human |
Immunogen | Recombinant fusion protein corresponding to aa. 21-140 of Human CD278 / ICOS (NP_036224.1). |
Conjugation | Un-conjugated |
Alternate Names | CD antigen CD278; CD278; Inducible T-cell costimulator; AILIM; Activation-inducible lymphocyte immunomediatory molecule; CVID1 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
Positive Control | Rat lung | ||||||||
Observed Size | 26 kDa |
Properties
Form | Liquid |
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Purification | Affinity purified. |
Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
Preservative | 0.02% Sodium azide |
Stabilizer | 50% Glycerol |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | ICOS |
Gene Full Name | inducible T-cell co-stimulator |
Background | The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008] |
Function | Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). [UniProt] |
Cellular Localization | Cell membrane, Single-pass type I membrane protein, Secreted. [UniProt] |
Calculated MW | 23 kDa |
PTM | N-glycosylated. [UniProt] |