ARG55533

anti-CD3 zeta antibody

anti-CD3 zeta antibody for Flow cytometry,Western blot and Human

Developmental Biology antibody; Immune System antibody

Overview

Product Description Rabbit Polyclonal antibody recognizes CD3 zeta
Tested Reactivity Hu
Predict Reactivity Pig
Tested Application FACS, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name CD3 zeta
Antigen Species Human
Immunogen KLH-conjugated synthetic peptide corresponding to aa. 2-31 (N-terminus) of Human CD3 zeta.
Conjugation Un-conjugated
Alternate Names IMD25; CD3Z; CD3-ZETA; T-cell surface glycoprotein CD3 zeta chain; CD3Q; T-cell receptor T3 zeta chain; CD3H; TCRZ; T3Z; CD antigen CD247

Application Instructions

Application Suggestion
Tested Application Dilution
FACS1:10 - 1:50
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control MOLT-4

Properties

Form Liquid
Purification Purification with Protein A and immunogen peptide.
Buffer PBS and 0.09% (W/V) Sodium azide
Preservative 0.09% (W/V) Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 919 Human CD247

Swiss-port # P20963 Human T-cell surface glycoprotein CD3 zeta chain

Gene Symbol CD247
Gene Full Name CD247 molecule
Background The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering. [UniProt]
Cellular Localization Membrane; Single-pass type I membrane protein
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Research Area Developmental Biology antibody; Immune System antibody
Calculated MW 19 kDa
PTM Phosphorylated on Tyr residues after T-cell receptor triggering.