ARG62410
anti-CD30 antibody [Ber-H2]
anti-CD30 antibody [Ber-H2] for IHC-Formalin-fixed paraffin-embedded sections,IHC-Frozen sections and Human
Cancer antibody; Immune System antibody
Overview
| Product Description | Mouse Monoclonal antibody [Ber-H2] recognizes CD30 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-Fr, IHC-P |
| Specificity | Reacts with mononuclear cells in Hodgkin lymphoma, Reed-Sternberg cells and most anaplastic large cell lymphomas. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | Ber-H2 |
| Isotype | IgG1 |
| Target Name | CD30 |
| Antigen Species | Human |
| Immunogen | BALB/C mice were injected with L428 cell line cells |
| Conjugation | Un-conjugated |
| Alternate Names | Tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30; Ki-1; Lymphocyte activation antigen CD30; CD antigen CD30; D1S166E; CD30L receptor |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | PBS and 0.05% Sodium azide |
| Preservative | 0.05% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P28908 Human Tumor necrosis factor receptor superfamily member 8 |
|---|---|
| Gene Symbol | TNFRSF8 |
| Gene Full Name | tumor necrosis factor receptor superfamily, member 8 |
| Background | CD30 is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| Function | CD30 is a receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898). [UniProt] |
| Cellular Localization | Cytoplasm and Cell membrane. |
| Research Area | Cancer antibody; Immune System antibody |
| Calculated MW | 64 kDa |
| PTM | Phosphorylated on serine and tyrosine residues. |
Clone References
Clinicopathology, immunophenotype, T cell receptor gene rearrangement, Epstein-Barr virus status and p53 gene mutation of cutaneous extranodal NK/T-cell lymphoma, nasal-type.
IHC / Human
Composite lymphoma in the anterior mediastinum: a case report and review of the literature.
IHC / Human
Copy number alterations and expression profiles of candidate genes in a pulmonary inflammatory myofibroblastic tumor.
IHC / Human
Diagnostic and differential diagnostic criteria of lymphoid neoplasms in bone marrow trephine biopsies: a study of 87 cases.
IHC / Human
