ARG42659

anti-CD319 / SLAMF7 antibody

anti-CD319 / SLAMF7 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes CD319 / SLAMF7
Tested Reactivity Hu, Rat
Tested Application IHC-P
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name CD319 / SLAMF7
Antigen Species Human
Immunogen Recombinant fusion protein corresponding to aa. 23-226 of Human CD319 / SLAMF7 (NP_067004.3).
Conjugation Un-conjugated
Alternate Names CD2-like receptor-activating cytotoxic cells; Protein 19A; CS1; Membrane protein FOAP-12; 19A; CD antigen CD319; SLAM family member 7; CD319; CD2 subset 1; Novel Ly9; CRACC

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:50 - 1:200
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 57823 Human SLAMF7

Swiss-port # Q9NQ25 Human SLAM family member 7

Gene Symbol SLAMF7
Gene Full Name SLAM family member 7
Function Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).

Isoform 3 does not mediate any NK cell activation. [UniProt]
Cellular Localization Membrane; Single-pass type I membrane protein. [UniProt]
Calculated MW 37 kDa