ARG57571
anti-CD41-CD61 Complex antibody [PAC-1]
anti-CD41-CD61 Complex antibody [PAC-1] for Flow cytometry,Immunoprecipitation,ICC/IF and Human
Overview
Product Description | Mouse Monoclonal antibody [PAC-1] recognizes CD41-CD61 Complex |
---|---|
Tested Reactivity | Hu |
Tested Application | FACS, ICC/IF, IP |
Specificity | The antibody recognizes an activation-induced conformational epitope PAC-1 on CD41/CD61 complex (gpIIb/IIIa), also known as integrin alpha IIb beta 3, a receptor which mediates platelet aggregation. |
Host | Mouse |
Clonality | Monoclonal |
Clone | PAC-1 |
Isotype | IgM |
Target Name | CD41-CD61 Complex |
Antigen Species | Human |
Immunogen | Human platelets. |
Conjugation | Un-conjugated |
Alternate Names | GTA; GT; GPalpha IIb; PPP1R93; CD41; BDPLT2; BDPLT16; GP2B; Integrin alpha-IIb; GPIIb; Platelet membrane glycoprotein IIb; HPA3; CD antigen CD41; CD41B |
Application Instructions
Application Suggestion |
|
||||||||
---|---|---|---|---|---|---|---|---|---|
Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
---|---|
Purification | PEG precipitation and hydroxyapatite chromatography. |
Purity | > 95% (by SDS-PAGE) |
Buffer | Tris buffered saline (pH 8.0) and 15 mM Sodium azide. |
Preservative | 15mM Sodium azide |
Concentration | 1 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
---|---|
Gene Symbol | ITGA2B |
Gene Full Name | ITGA2B |
Background | ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008] |
Function | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. [UniProt] |
Calculated MW | 113 kDa |