ARG42297

anti-CD42a antibody [GR-P] (APC)

anti-CD42a antibody [GR-P] (APC) for Flow cytometry and Dog,Human

Overview

Product Description APC-conjugated Mouse Monoclonal antibody [GR-P] recognizes CD42a
Tested Reactivity Hu, Dog
Tested Application FACS
Specificity The mouse monoclonal antibody GR-P (also known as GRP-P) recognizes an extracellular epitope of CD42a (glycoprotein 9), a 22 kDa transmembrane protein constitutively expressed on megakaryocytes and platelets.
Host Mouse
Clonality Monoclonal
Clone GR-P
Isotype IgG1
Target Name CD42a
Antigen Species Human
Immunogen Human acute lymphoblastic leukemia cells.
Conjugation APC
Alternate Names Glycoprotein 9; CD antigen CD42a; CD42a; GPIX; GP-IX; Platelet glycoprotein IX

Application Instructions

Application Suggestion
Tested Application Dilution
FACS10 µl / 100 µl of whole blood or 10^6 cells
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified
Buffer PBS and 15 mM Sodium azide.
Preservative 15 mM Sodium azide
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 2815 Human GP9

Swiss-port # P14770 Human Platelet glycoprotein IX

Gene Symbol GP9
Gene Full Name glycoprotein IX (platelet)
Background This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. [provided by RefSeq, Oct 2008]
Function The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib. [UniProt]
Cellular Localization Membrane; Single-pass type I membrane protein. [UniProt]
Calculated MW 19 kDa