ARG53866
anti-CD48 antibody [MEM-102] (PE)
anti-CD48 antibody [MEM-102] (PE) for Flow cytometry and Human,Primates
Immune System antibody
Overview
| Product Description | PE-conjugated Mouse Monoclonal antibody [MEM-102] recognizes CD48 |
|---|---|
| Tested Reactivity | Hu, NHuPrm |
| Tested Application | FACS |
| Specificity | The clone MEM-102 reacts with CD48 antigen (Blast-1), a 40-47 kDa GPI-anchored membrane protein (immunoglobulin supergene family) widely expressed on hematopoietic cells; it is negative on granulocytes, platelets and erythrocytes. HLDA V; WS Code AS S014 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | MEM-102 |
| Isotype | IgG1 |
| Target Name | CD48 |
| Antigen Species | Human |
| Immunogen | Raji human Burkitt's lymphoma cell line |
| Conjugation | PE |
| Alternate Names | Leukocyte antigen MEM-102; B-lymphocyte activation marker BLAST-1; CD48 antigen; BCM1 surface antigen; CD antigen CD48; TCT.1; BLAST1; BCM1; MEM-102; mCD48; Signaling lymphocytic activation molecule 2; BLAST; hCD48; SLAMF2; SLAM family member 2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification Note | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| Buffer | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| Preservative | 15 mM Sodium azide |
| Stabilizer | 0.2% (w/v) high-grade protease free BSA |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CD48 |
| Gene Full Name | CD48 molecule |
| Background | CD48 (Blast-1) belongs to the CD2 subset of the Ig superfamily, which includes CD2, CD2F-10, CD58, CD84, CD150, CD229, CD244 and others. These molecules bind to the same or another members of their family, thus mediate homotypic or heterotypic adhesion. CD48 is a GPI-anchored protein broadly expressed on hematopoietic cells and serves as a high affinity ligand for 2B4 and low affinity ligand for CD2. 2B4-CD48 interaction among NK cells and NK-T cells regulates cell proliferation. Signaling through CD48 results in eosinophil activation and CD48 expression is increased in several infectious diseases. |
| Function | Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. [UniProt] |
| Research Area | Immune System antibody |
| Calculated MW | 28 kDa |
Clone References
Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement.
Signal transduction via glycosyl phosphatidylinositol-anchored proteins in T cells is inhibited by lowering cellular cholesterol.
Monoclonal antibodies against human leucocyte antigens. III. Antibodies against CD45R, CD6, CD44 and two newly described broadly expressed glycoproteins MEM-53 and MEM-102.
The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1.
