ARG22496

anti-CD49a / Integrin alpha 1 antibody [TS2/7] (FITC)

anti-CD49a / Integrin alpha 1 antibody [TS2/7] (FITC) for Flow cytometry and Human

Overview

Product Description FITC-conjugated Mouse Monoclonal antibody [TS2/7] recognizes CD49a / Integrin alpha 1
This antibody recognizes the human alpha 1 integrin sub-unit, which forms the VLA-1 heterodimer in association with the beta 1 integrin. VLA-1 is a receptor for collagen and laminin, and is expressed by chronically activated T cells, melanoma cells and smooth muscle cells.
Tested Reactivity Hu
Tested Application FACS
Host Mouse
Clonality Monoclonal
Clone TS2/7
Isotype IgG1
Target Name CD49a / Integrin alpha 1
Antigen Species Human
Immunogen Human CTL line directed against HLA-DR.
Conjugation FITC
Alternate Names VLA-1; CD49a; Integrin alpha-1; Laminin and collagen receptor; VLA1; CD antigen CD49a; CD49 antigen-like family member A

Application Instructions

Application Suggestion
Tested Application Dilution
FACSNeat - 1:10
Application Note FACS: Use 10ul of the suggested working dilution to label 10^6 cells in 100ul.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purification with Protein G.
Buffer PBS, 0.09% Sodium azide and 1% BSA.
Preservative 0.09% Sodium azide
Stabilizer 1% BSA
Concentration 0.1 mg/ml
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 3672 Human ITGA1

Swiss-port # P56199 Human Integrin alpha-1

Gene Symbol ITGA1
Gene Full Name integrin, alpha 1
Background This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]
Function Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. [UniProt]
Calculated MW 131 kDa