ARG23083
anti-CD49d / LPAM1 / Integrin alpha 4 antibody [HP2/1]
anti-CD49d / LPAM1 / Integrin alpha 4 antibody [HP2/1] for IHC-Frozen sections,Flow cytometry,Functional study,Immunoprecipitation and Human,Rat,Rhesus Monkey,Bovine,Pig,Goat,Rabbit,Horse,Cat
Overview
| Product Description | Mouse Monoclonal antibody [HP2/1] recognizes CD49d / LPAM1 / Integrin alpha 4 |
|---|---|
| Tested Reactivity | Hu, Rat, Bov, Cat, Goat, Hrs, Pig, R. Mk, Rb |
| Tested Application | FACS, FuncSt, IHC-Fr, IP |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | HP2/1 |
| Isotype | IgG1 |
| Target Name | CD49d / LPAM1 / Integrin alpha 4 |
| Antigen Species | Human |
| Immunogen | JM leukaemia line. |
| Conjugation | Un-conjugated |
| Alternate Names | CD49 antigen-like family member D; VLA-4 subunit alpha; CD49D; Integrin alpha-IV; CD antigen CD49d; Integrin alpha-4; IA4 |
Application Instructions
| Application Suggestion |
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| Application Note | Functional study: This product contains sodium azide, removal by dialysis is recommended prior to use in functional assays. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified |
| Buffer | PBS and 0.09% Sodium azide |
| Preservative | 0.09% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ITGA4 |
| Gene Full Name | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
| Background | The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq, Jul 2008] |
| Function | Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. [UniProt] |
| Calculated MW | 115 kDa |
| PTM | Phosphorylation on Ser-1027 inhibits PXN binding. |
