ARG54039
anti-CD54 / ICAM1 antibody
anti-CD54 / ICAM1 antibody for Western blot,ICC/IF and Human
Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody; Cytotoxic T Cell Surface Study antibody
Overview
Product Description | Mouse Monoclonal antibody recognizes CD54 / ICAM1 |
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Tested Reactivity | Hu |
Tested Application | ICC/IF, WB |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG2b |
Target Name | CD54 / ICAM1 |
Antigen Species | Human |
Immunogen | Purified recombinant human CD54 / ICAM1 protein fragments expressed in E.coli. |
Conjugation | Un-conjugated |
Alternate Names | CD54; CD antigen CD54; BB2; P3.58; Intercellular adhesion molecule 1; Major group rhinovirus receptor; ICAM-1 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
Observed Size | 96 kDa |
Properties
Form | Liquid |
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Purification | Affinity purified |
Buffer | PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol |
Preservative | 0.02% Sodium azide |
Stabilizer | 50% Glycerol |
Concentration | 2.5 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | ICAM1 |
Gene Full Name | intercellular adhesion molecule 1 |
Background | This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008] |
Function | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). [UniProt] |
Cellular Localization | Membrane; Single-pass type I membrane protein. |
Research Area | Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody; Cytotoxic T Cell Surface Study antibody |
Calculated MW | 58 kDa |
PTM | Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. |