ARG65850
anti-CD6 antibody [MRC OX-52] (FITC)
anti-CD6 antibody [MRC OX-52] (FITC) for Flow cytometry and Rat
Overview
| Product Description | FITC-conjugated Mouse Monoclonal antibody [MRC OX-52] recognizes CD6 |
|---|---|
| Tested Reactivity | Rat |
| Tested Application | FACS |
| Specificity | This monoclonal antibody immunoprecipitates a two chain structure (95, 120 kDa) largely restricted to T lymphocytes and thymocytes. This clone does not inhibit the allogeneic mixed leukocyte response, nor does it inhibit T cytotoxic effector cell function. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | MRC OX-52 |
| Isotype | IgG2a |
| Target Name | CD6 |
| Antigen Species | Rat |
| Immunogen | Rat CD6 |
| Conjugation | FITC |
| Alternate Names | CD antigen CD6; TP120; T-cell differentiation antigen CD6; T12 |
Application Instructions
| Application Suggestion |
|
||||
|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified. |
| Buffer | PBS (pH 7.2), 0.09% Sodium azide and 1% BSA. |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 1% BSA |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | Cd6 |
|---|---|
| Gene Full Name | Cd6 molecule |
| Background | This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| Function | Involved in cell adhesion. Binds to CD166. [UniProt] |
| Calculated MW | 72 kDa |
| PTM | After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues. Glycosylated. |
