ARG22498
anti-CD66a + CD66c + CD66d antibody [YTH71.3]
anti-CD66a + CD66c + CD66d antibody [YTH71.3] for IHC-Frozen sections,Flow cytometry and Human,Rhesus Monkey
Overview
| Product Description | Rat Monoclonal antibody [YTH71.3] recognizes CD66a + CD66c + CD66d This antibody recognizes 3 members of the human CD66 family, namely CD66a, CD66c and CD66d. CD66 members are expressed by human neutrophils and cells of the colon where it is down regulated in some cases of colon carcinoma (Neumaier et al. 2012). CD66a is also expressed in the human alveolar adenocarcinoma cell line A549 and may play a role in Moraxella catarrhalis induced apoptosis of pulmonary epithlial cells in diseases including COPD and emphysema (N'Guessan et al. 2007). |
|---|---|
| Tested Reactivity | Hu, R. Mk |
| Species Does Not React With | Ms |
| Tested Application | FACS, IHC-Fr |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | YTH71.3 |
| Isotype | IgG2a |
| Target Name | CD66a + CD66c + CD66d |
| Antigen Species | Human |
| Immunogen | Human lymphocytes |
| Conjugation | Un-conjugated |
| Alternate Names | Normal cross-reacting antigen; Carcinoembryonic antigen-related cell adhesion molecule 6; CEAL; CD66c; CD antigen CD66c; NCA; Non-specific crossreacting antigen |
Application Instructions
| Application Suggestion |
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| Application Note | FACS: Use 10ul of the suggested working dilution to label 10^6 cells in 100ul. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS and 0.09% Sodium azide |
| Preservative | 0.09% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P40199 Human Carcinoembryonic antigen-related cell adhesion molecule 6 |
|---|---|
| Gene Symbol | CEACAM6 |
| Gene Full Name | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) |
| Background | This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014] |
| Calculated MW | 37 kDa |
