ARG62918
anti-CD7 antibody [MEM-186]
anti-CD7 antibody [MEM-186] for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human
Immune System antibody
Overview
| Product Description | Mouse Monoclonal antibody [MEM-186] recognizes CD7 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, IHC-P, IP, WB |
| Specificity | The clone MEM-186 reacts with CD7, a 40 kD type I transmembrane glycoprotein expressed on peripheral blood T lymphocytes, NK-cells, hematopoietic progenitors, monocytes (weakly) and also on acute lymphocytic leukemia. HLDA VI; WS Code T 6T-015 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | MEM-186 |
| Isotype | IgG1 |
| Target Name | CD7 |
| Antigen Species | Human |
| Immunogen | Human acute myelogenous leukaemia cell line KG-1. |
| Conjugation | Un-conjugated |
| Alternate Names | TP41; Tp40; T-cell antigen CD7; CD antigen CD7; T-cell leukemia antigen; LEU-9; T-cell surface antigen Leu-9; GP40 |
Application Instructions
| Application Suggestion |
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| Application Note | WB: Under non-reducing condition. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| Positive Control | IHC-P: Spleen |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified by protein A |
| Purity | > 95% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) and 15 mM Sodium azide |
| Preservative | 15 mM Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CD7 |
| Gene Full Name | CD7 molecule |
| Background | CD7, also known as gp40, is a member of the immunoglobulin superfamily found on T cells, NK cells, thymocytes, hematopoietic progenitors, and monocytes (weakly). CD7 is also expressed on acute lymphocytic leukemia (ALL). CD7 crosslinking induces a calcium flux in T lymphocytes, presumably as a result of cytoplasmic domain association with PI3-kinase. CD7 co-stimulation can induce cytokine secretion and modulate cellular adhesion. A ligand of CD7, epithelial cell secreted protein K12, is produced in thymus to regulate thymocyte signaling and cytokine release. In lung microvascular endothelial cells CD7 serves as an IgM Fc receptor. Expression of CD7 is an important marker used in leukemia diagnostics. |
| Function | Not yet known. [UniProt] |
| Highlight | Related products: CD7 antibodies; CD7 ELISA Kits; CD7 Duos / Panels; Anti-Mouse IgG secondary antibodies; Related news: Lymphoma |
| Research Area | Immune System antibody |
| Calculated MW | 25 kDa |
