ARG44614
anti-CD70 antibody [Ki-24] (APC)
anti-CD70 antibody [Ki-24] (APC) for Flow cytometry and Human
Overview
| Product Description | APC-conjugated Mouse Monoclonal antibody recognizes CD70 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | Ki-24 |
| Isotype | IgG3 kappa |
| Target Name | CD70 |
| Antigen Species | Human |
| Conjugation | APC |
| Alternate Names | CD70; CD70 Molecule; CD27-L; CD27L; CD70 Antigen; CD27 Ligand; CD27LG; TNFSF7; Tumor Necrosis Factor Ligand Superfamily Member 7; Tumor Necrosis Factor (Ligand) Superfamily, Member 7; Tumor Necrosis Factor Ligand 8A; Surface Antigen CD70; Ki-24 Antigen; TNLG8A; LPFS3 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified antibody is conjugated with activated allophycocyanin (APC), and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography. |
| Buffer | PBS (pH 7.4) and 15 mM Sodium azide |
| Preservative | 15 mM Sodium azide |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CD70 |
| Gene Full Name | CD70 Molecule |
| Background | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008] |
| Function | The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells. [UniProt] |
| Cellular Localization | Cell membrane, Membrane. [UniProt] |
| Calculated MW | 21 kDa |
| PTM | Disulfide bond, Glycoprotein. [UniProt] |
