ARG42337

anti-CD70 antibody [Ki-24] (PE)

anti-CD70 antibody [Ki-24] (PE) for Flow cytometry and Human

Overview

Product Description PE-conjugated Mouse Monoclonal antibody [Ki-24] recognizes CD70
Tested Reactivity Hu
Tested Application FACS
Specificity The mouse monoclonal antibody Ki-24 recognizes an extracellular epitope of CD70, an approximately 50 kDa type II transmembrane glycoprotein expressed on activated lymphocytes and some B cell leukemias.
Host Mouse
Clonality Monoclonal
Clone Ki-24
Isotype IgG3, kappa
Target Name CD70
Antigen Species Human
Immunogen Human CD70.
Conjugation PE
Alternate Names CD27 ligand; CD70 antigen; Tumor necrosis factor ligand superfamily member 7; CD antigen CD70; CD27L; CD27-L; TNFSF7; CD27LG

Application Instructions

Application Suggestion
Tested Application Dilution
FACS10 µl / 100 µl of whole blood or 10^6 cells
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified
Buffer PBS and 15 mM Sodium azide.
Preservative 15 mM Sodium azide
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 970 Human CD70

Swiss-port # P32970 Human CD70 antigen

Gene Symbol CD70
Gene Full Name CD70 molecule
Background The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
Function Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. [UniProt]
Cellular Localization Membrane; Single-pass type II membrane protein. [UniProt]
Calculated MW 21 kDa