ARG42337
anti-CD70 antibody [Ki-24] (PE)
anti-CD70 antibody [Ki-24] (PE) for Flow cytometry and Human
Overview
Product Description | PE-conjugated Mouse Monoclonal antibody [Ki-24] recognizes CD70 |
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Tested Reactivity | Hu |
Tested Application | FACS |
Specificity | The mouse monoclonal antibody Ki-24 recognizes an extracellular epitope of CD70, an approximately 50 kDa type II transmembrane glycoprotein expressed on activated lymphocytes and some B cell leukemias. |
Host | Mouse |
Clonality | Monoclonal |
Clone | Ki-24 |
Isotype | IgG3, kappa |
Target Name | CD70 |
Antigen Species | Human |
Immunogen | Human CD70. |
Conjugation | PE |
Alternate Names | CD27 ligand; CD70 antigen; Tumor necrosis factor ligand superfamily member 7; CD antigen CD70; CD27L; CD27-L; TNFSF7; CD27LG |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification | Purified |
Buffer | PBS and 15 mM Sodium azide. |
Preservative | 15 mM Sodium azide |
Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | CD70 |
Gene Full Name | CD70 molecule |
Background | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008] |
Function | Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. [UniProt] |
Cellular Localization | Membrane; Single-pass type II membrane protein. [UniProt] |
Calculated MW | 21 kDa |