ARG42412
anti-CD85g / ILT7 antibody [17G10.2]
anti-CD85g / ILT7 antibody [17G10.2] for Flow cytometry and Human
Overview
| Product Description | Mouse Monoclonal antibody [17G10.2] recognizes CD85g / ILT7 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS |
| Specificity | The mouse monoclonal antibody 17G10.2 recognizes an extracellular epitope of CD85g / ILT7, a member of leukocyte immunoglobulin-like receptor family expressed on plasmacytoid dendritic cells, but not on myeloid dendritic cells and other peripheral blood leukocytes. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 17G10.2 |
| Isotype | IgG1, kappa |
| Target Name | CD85g / ILT7 |
| Antigen Species | Human |
| Immunogen | Human CD85g / ILT7–FcεRIγ-transfected 2B4 cells. |
| Conjugation | Un-conjugated |
| Alternate Names | ILT7; ILT-7; CD85 antigen-like family member G; Immunoglobulin-like transcript 7; CD antigen CD85g; CD85g; Leukocyte immunoglobulin-like receptor subfamily A member 4 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS and 15 mM Sodium azide. |
| Preservative | 15 mM Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P59901 Human Leukocyte immunoglobulin-like receptor subfamily A member 4 |
|---|---|
| Gene Symbol | LILRA4 |
| Gene Full Name | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 |
| Background | This gene encodes an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response. Expression of this gene is downregulated by interleukin 3 (IL3). This gene is one of a cluster of highly related genes located at chromosomal region 19q13.4. [provided by RefSeq, Jan 2015] |
| Function | Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760). [UniProt] |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. [UniProt] |
| Calculated MW | 55 kDa |
