ARG42293

anti-CD89 antibody [A59] (FITC)

anti-CD89 antibody [A59] (FITC) for Flow cytometry and Human,Primates

Overview

Product Description FITC-conjugated Mouse Monoclonal antibody [A59] recognizes CD89
Tested Reactivity Hu, NHuPrm
Tested Application FACS
Specificity The mouse monoclonal antibody A59 recognizes an extracellular epitope of CD89, a 55-100 kDa glycoprotein serving as a receptor for IgA and expressed mainly on granulocytes, monocytes and macrophages.
Host Mouse
Clonality Monoclonal
Clone A59
Isotype IgG1, kappa
Target Name CD89
Antigen Species Human
Immunogen Ag8.653 myeloma cells.
Conjugation FITC
Alternate Names CD89; CTB-61M7.2; FcalphaRI; CD antigen CD89; Immunoglobulin alpha Fc receptor; IgA Fc receptor

Application Instructions

Application Suggestion
Tested Application Dilution
FACS4 µl / 100 µl of whole blood or 10^6 cells
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified
Buffer PBS and 15 mM Sodium azide.
Preservative 15 mM Sodium azide
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 2204 Human FCAR

Swiss-port # P24071 Human Immunoglobulin alpha Fc receptor

Gene Symbol FCAR
Gene Full Name Fc fragment of IgA receptor
Background This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Function Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. [UniProt]
Cellular Localization Isoform A.1: Cell membrane; Single-pass type I membrane protein. Isoform A.2: Cell membrane; Single-pass type I membrane protein. Isoform A.3: Cell membrane; Single-pass type I membrane protein. Isoform B: Secreted. Isoform B-delta-S2: Secreted. [UniProt]
Calculated MW 32 kDa