ARG42293
anti-CD89 antibody [A59] (FITC)
anti-CD89 antibody [A59] (FITC) for Flow cytometry and Human,Primates
Overview
| Product Description | FITC-conjugated Mouse Monoclonal antibody [A59] recognizes CD89 |
|---|---|
| Tested Reactivity | Hu, NHuPrm |
| Tested Application | FACS |
| Specificity | The mouse monoclonal antibody A59 recognizes an extracellular epitope of CD89, a 55-100 kDa glycoprotein serving as a receptor for IgA and expressed mainly on granulocytes, monocytes and macrophages. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | A59 |
| Isotype | IgG1, kappa |
| Target Name | CD89 |
| Antigen Species | Human |
| Immunogen | Ag8.653 myeloma cells. |
| Conjugation | FITC |
| Alternate Names | CD89; CTB-61M7.2; FcalphaRI; CD antigen CD89; Immunoglobulin alpha Fc receptor; IgA Fc receptor |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified |
| Buffer | PBS and 15 mM Sodium azide. |
| Preservative | 15 mM Sodium azide |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | FCAR |
| Gene Full Name | Fc fragment of IgA receptor |
| Background | This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| Function | Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. [UniProt] |
| Cellular Localization | Isoform A.1: Cell membrane; Single-pass type I membrane protein. Isoform A.2: Cell membrane; Single-pass type I membrane protein. Isoform A.3: Cell membrane; Single-pass type I membrane protein. Isoform B: Secreted. Isoform B-delta-S2: Secreted. [UniProt] |
| Calculated MW | 32 kDa |
