ARG22519
anti-CD89 antibody [MIP8a] (low endotoxin)
anti-CD89 antibody [MIP8a] (low endotoxin) for ELISA,Flow cytometry,Functional study,Immunoprecipitation,Western blot and Human
Overview
| Product Description | Azide free and low endotoxin Mouse Monoclonal antibody [MIP8a] recognizes CD89 This antibody recognizes the human CD89 cell surface antigen, a 50-75kDa cell surface glycoprotein that is also known as the IgA receptor (Fc alpha R).CD89 is expressed by peripheral blood monocytes and neutrophils.MIP8a blocks binding of IgA to the Fc alpha R, and also inhibits neutrophil phagocytosis of IgA complexes. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA, FACS, FuncSt, IP, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | MIP8a |
| Isotype | IgG1 |
| Target Name | CD89 |
| Antigen Species | Human |
| Immunogen | Recombinant soluble human Fc alpha R. |
| Conjugation | Un-conjugated |
| Alternate Names | CD89; CTB-61M7.2; FcalphaRI; CD antigen CD89; Immunoglobulin alpha Fc receptor; IgA Fc receptor |
Application Instructions
| Application Suggestion |
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| Application Note | FACS: Use 10ul of the suggested working dilution to label 10^6 cells or 100ul whole blood * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified |
| Purification Note | Low endotoxin |
| Buffer | PBS |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | FCAR |
| Gene Full Name | Fc fragment of IgA receptor |
| Background | This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| Function | Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. [UniProt] |
| Calculated MW | 32 kDa |
