ARG58379
anti-CEACAM3 antibody
anti-CEACAM3 antibody for Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CEACAM3 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CEACAM3 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-135 of Human CEACAM3 (NP_001806.2). |
| Conjugation | Un-conjugated |
| Alternate Names | CGM1; W282; Carcinoembryonic antigen CGM1; CEA; Carcinoembryonic antigen-related cell adhesion molecule 3; W264; CD66D; CD antigen CD66d |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Mouse lung | ||||
| Observed Size | 27 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P40198 Human Carcinoembryonic antigen-related cell adhesion molecule 3 |
|---|---|
| Gene Symbol | CEACAM3 |
| Gene Full Name | carcinoembryonic antigen-related cell adhesion molecule 3 |
| Background | This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013] |
| Function | Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. [UniProt] |
| Cellular Localization | Membrane, Single-pass type I membrane protein. [UniProt] |
| Calculated MW | 27 kDa |
| PTM | Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected. [UniProt] |
