ARG65094
anti-CEP290 antibody
anti-CEP290 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections and Human
Gene Regulation antibody; Neuroscience antibody
Overview
| Product Description | Goat Polyclonal antibody recognizes CEP290 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, IHC-P |
| Specificity | Despite similarity of the immunizing peptide with the mouse protein, this antibody was demonstrated to weak for mouse Cep290. |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CEP290 |
| Antigen Species | Human |
| Immunogen | C-RNSKHLKQQQYRAEN |
| Conjugation | Un-conjugated |
| Alternate Names | NPHP6; rd16; Bardet-Biedl syndrome 14 protein; JBTS5; Tumor antigen se2-2; POC3; SLSN6; Nephrocystin-6; LCA10; BBS14; Centrosomal protein of 290 kDa; Cancer/testis antigen 87; Cep290; 3H11Ag; CT87; MKS4 |
Application Instructions
| Application Suggestion |
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| Application Note | IHC-P: Antigen Retrieval: Heat mediation was performed in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from goat serum by antigen affinity chromatography. |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Background | This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer. [provided by RefSeq, Jul 2008] |
| Research Area | Gene Regulation antibody; Neuroscience antibody |
| Calculated MW | 290 kDa |
| PTM | Ubiquitinated. May undergo monoubiquitination; monoubiquitination is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, but does not cause it displacement from centriolar satellites. |
