ARG23507
anti-CGRP antibody
anti-CGRP antibody for IHC-Frozen sections,ELISA,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections and Mouse,Guinea pig,Rat
Overview
| Product Description | Goat Polyclonal antibody recognizes CGRP. Goat anti Rat Calcitonin Gene-Related Peptide antibody recognizes Calcitonin gene-related peptide, also known as CGRP, a neuropeptide that acts as a vasodilator and plays a role in in the pathophysiology of migraine (Recober & Russo 2009). Goat anti Rat Calcitonin Gene-Related Peptide antibody reacts with both the whole molecule (amino acids 1-37) and the C-terminal fragment (23-37). |
|---|---|
| Tested Reactivity | Ms, Rat, Gpig |
| Tested Application | ELISA, ICC/IF, IHC-Fr, IHC-P |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CGRP |
| Antigen Species | Rat |
| Immunogen | Synthetic Rat Tyr-CGRP (23-37) conjugated to gamma globulin. |
| Conjugation | Un-conjugated |
| Alternate Names | CALC1; CGRP-I; Calcitonin gene-related peptide 1; CGRP1; Calcitonin gene-related peptide I; Alpha-type CGRP; CGRP |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS and 0.09% Sodium azide. |
| Preservative | 0.09% Sodium azide |
| Concentration | 5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | CALCA |
|---|---|
| Gene Full Name | Calcitonin gene-related peptide 1 |
| Background | This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2014] |
| Function | CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. [UniProt] |
| Calculated MW | 14 kDa |
