ARG41825
anti-CHD4 antibody
anti-CHD4 antibody for Western blot,ICC/IF,Flow cytometry and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CHD4 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CHD4 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of Human CHD4. |
| Conjugation | Un-conjugated |
| Alternate Names | Chromodomain-helicase-DNA-binding protein 4; Mi-2b; EC 3.6.4.12; Mi-2 autoantigen 218 kDa protein; CHD-4; Mi2-beta; ATP-dependent helicase CHD4; Mi2-BETA |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | 293T |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q14839 Human Chromodomain-helicase-DNA-binding protein 4 |
|---|---|
| Gene Symbol | CHD4 |
| Gene Full Name | chromodomain helicase DNA binding protein 4 |
| Background | The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014] |
| Function | Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. [UniProt] |
| Cellular Localization | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrosomes in interphase. [UniProt] |
| Calculated MW | 218 kDa |
