ARG42536
anti-CHML / REP2 antibody
anti-CHML / REP2 antibody for Western blot and Human,Mouse,Rat,Dog,Monkey
Overview
| Product Description | Goat Polyclonal antibody recognizes CHML / REP2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat, Dog, Mk |
| Tested Application | WB |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CHML / REP2 |
| Antigen Species | Human |
| Immunogen | Purified recombinant peptide within aa. 617 to the C-terminus of Human CHML / REP2. |
| Conjugation | Un-conjugated |
| Alternate Names | Rab proteins geranylgeranyltransferase component A 2; Choroideremia-like protein; REP2; Rab escort protein 2; REP-2 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | LS174T and HeLa | ||||
| Observed Size | ~ 80 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS, 0.05% Sodium azide and 20% Glycerol. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 20% Glycerol |
| Concentration | 3 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P26374 Human Rab proteins geranylgeranyltransferase component A 2 Swiss-port # Q9QZD5 Mouse Rab proteins geranylgeranyltransferase component A 2 |
|---|---|
| Gene Symbol | CHML |
| Gene Full Name | choroideremia-like (Rab escort protein 2) |
| Background | The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008] |
| Function | Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family. [UniProt] |
| Cellular Localization | Cytoplasm, cytosol. [UniProt] |
| Calculated MW | 74 kDa |
