ARG42536

anti-CHML / REP2 antibody

anti-CHML / REP2 antibody for Western blot and Human,Mouse,Rat,Dog,Monkey

Overview

Product Description Goat Polyclonal antibody recognizes CHML / REP2
Tested Reactivity Hu, Ms, Rat, Dog, Mk
Tested Application WB
Host Goat
Clonality Polyclonal
Isotype IgG
Target Name CHML / REP2
Antigen Species Human
Immunogen Purified recombinant peptide within aa. 617 to the C-terminus of Human CHML / REP2.
Conjugation Un-conjugated
Alternate Names Rab proteins geranylgeranyltransferase component A 2; Choroideremia-like protein; REP2; Rab escort protein 2; REP-2

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500 - 1:5000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control LS174T and HeLa
Observed Size ~ 80 kDa

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS, 0.05% Sodium azide and 20% Glycerol.
Preservative 0.05% Sodium azide
Stabilizer 20% Glycerol
Concentration 3 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 1122 Human CHML

GeneID: 12663 Mouse CHML

Swiss-port # P26374 Human Rab proteins geranylgeranyltransferase component A 2

Swiss-port # Q9QZD5 Mouse Rab proteins geranylgeranyltransferase component A 2

Gene Symbol CHML
Gene Full Name choroideremia-like (Rab escort protein 2)
Background The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008]
Function Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family. [UniProt]
Cellular Localization Cytoplasm, cytosol. [UniProt]
Calculated MW 74 kDa