ARG58430
anti-CHRNA1 / Nicotinic Acetylcholine R alpha 1 antibody
anti-CHRNA1 / Nicotinic Acetylcholine R alpha 1 antibody for Western blot and Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CHRNA1 / Nicotinic Acetylcholine R alpha 1 |
|---|---|
| Tested Reactivity | Rat |
| Predict Reactivity | Hm |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CHRNA1 / Nicotinic Acetylcholine R alpha 1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to aa. 22-36 of Human Nicotinic Acetylcholine Receptor alpha 1 (EHETRLVAKLFKDYS). Identical to the related Rat sequence, different from the related Mouse sequence by one amino acid. |
| Conjugation | Un-conjugated |
| Alternate Names | CMS1A; FCCMS; CMS1B; SCCMS; CMS2A; Acetylcholine receptor subunit alpha; CHRNA; ACHRA; ACHRD |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA. |
| Preservative | 0.05% Thimerosal and 0.05% Sodium azide |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P25108 Rat Acetylcholine receptor subunit alpha |
|---|---|
| Gene Symbol | CHRNA1 |
| Gene Full Name | cholinergic receptor, nicotinic, alpha 1 (muscle) |
| Background | The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2012] |
| Function | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. [UniProt] |
| Cellular Localization | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. [UniProt] |
| Calculated MW | 55 kDa |
