ARG44641

anti-CLASP1 antibody

anti-CLASP1 antibody for Immunoprecipitation,Western blot and Human,Mouse

Overview

Product Description Rat Monoclonal antibody recognizes CLASP1
Tested Reactivity Hu, Ms
Tested Application IP, WB
Host Rat
Clonality Monoclonal
Isotype IgG2a
Target Name CLASP1
Antigen Species Mouse
Conjugation Un-conjugated
Alternate Names CLASP1; Cytoplasmic Linker Associated Protein 1; MAST1; CLIP-Associating Protein 1; KIAA0622; Multiple Asters Homolog 1; Protein Orbit Homolog 1; Multiple Asters 1; Cytoplasmic Linker-Associated Protein 1; HOrbit1

Application Instructions

Application Suggestion
Tested Application Dilution
IP10 µg/mL
WB1 µg/mL
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Protein A purification
Buffer PBS with 0.09% sodium azide
Preservative 0.09% sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 23332 Human CLASP1

GeneID: 76707 Mouse CLASP1

Swiss-port # Q7Z460 Human CLIP-associating protein 1

Swiss-port # Q80TV8 Mouse CLIP-associating protein 1

Gene Symbol CLASP1
Gene Full Name Cytoplasmic Linker Associated Protein 1
Background CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]
Function Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. [UniProt]
Cellular Localization Centromere, Chromosome, Cytoplasm, Cytoskeleton, Golgi apparatus, Kinetochore, Microtubule. [UniProt]
Calculated MW 169 kDa
PTM Phosphoprotein. [UniProt]