ARG57007
anti-CMBL antibody [2B11]
anti-CMBL antibody [2B11] for Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody [2B11] recognizes CMBL |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 2B11 |
| Isotype | IgG2a, kappa |
| Target Name | CMBL |
| Antigen Species | Human |
| Immunogen | Recombinant fragment around aa. 1-245 of Human CMBL. |
| Conjugation | Un-conjugated |
| Alternate Names | JS-1; Carboxymethylenebutenolidase homolog; EC 3.1.-.- |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 10% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q96DG6 Human Carboxymethylenebutenolidase homolog |
|---|---|
| Gene Symbol | CMBL |
| Gene Full Name | carboxymethylenebutenolidase homolog (Pseudomonas) |
| Background | CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]).[supplied by OMIM, Apr 2010] |
| Function | Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. [UniProt] |
| Calculated MW | 28 kDa |
