ARG44644
anti-CMTM6 antibody
anti-CMTM6 antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes CMTM6 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, IP, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | CMTM6 |
| Antigen Species | Human |
| Conjugation | Un-conjugated |
| Alternate Names | CMTM6; CKLF Like MARVEL Transmembrane Domain Containing 6; CKLFSF6; CKLF-Like MARVEL Transmembrane Domain-Containing Protein 6; Chemokine-Like Factor Superfamily Member 6; Chemokine-Like Factor Super Family 6; Chemokine-Like Factor Superfamily 6; FLJ20396; CKLF-Like MARVEL Transmembrane Domain Containing 6; PRO2219 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9NX76 Human CKLF-like MARVEL transmembrane domain-containing protein 6 |
|---|---|
| Gene Symbol | CMTM6 |
| Gene Full Name | CKLF Like MARVEL Transmembrane Domain Containing 6 |
| Background | This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008] |
| Function | Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. [UniProt] |
| Cellular Localization | Cell membrane, Endosome, Membrane. [UniProt] |
| Calculated MW | 20 kDa |
| PTM | Acetylation, Phosphoprotein. [UniProt] |
