ARG41131

anti-CNOT9 / RQCD1 antibody

anti-CNOT9 / RQCD1 antibody for Western blot and Human

Overview

Product Description Rabbit Polyclonal antibody recognizes CNOT9 / RQCD1
Tested Reactivity Hu
Predict Reactivity Ms
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name CNOT9 / RQCD1
Antigen Species Human
Immunogen KLH-conjugated synthetic peptide between aa. 106-134 of Human CNOT9 / RQCD1.
Conjugation Un-conjugated
Alternate Names RCD-1; Rcd-1; RCD1; Cell differentiation protein RCD1 homolog; CNOT9; CT129; CCR4-NOT transcription complex subunit 9; CAF40

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purification with Protein A and immunogen peptide
Buffer PBS and 0.09% (W/V) Sodium azide.
Preservative 0.09% (W/V) Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 9125 Human RQCD1

Swiss-port # Q92600 Human Cell differentiation protein RCD1 homolog

Gene Symbol RQCD1
Gene Full Name RCD1 required for cell differentiation1 homolog (S. pombe)
Background This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012]
Function Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. [UniProt]
Cellular Localization Nucleus. Cytoplasm, P-body. Note=NANOS2 promotes its localization to P-body. [UniProt]
Calculated MW 34 kDa