ARG62449

anti-CNPase antibody [11-5B]

anti-CNPase antibody [11-5B] for Conjugation,Dot blot,ELISA,Flow cytometry,ICC/IF,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat,Dog,Rhesus Monkey

Controls and Markers antibody; Neuroscience antibody

Overview

Product Description Mouse Monoclonal antibody [11-5B] recognizes CNPase
Tested Reactivity Hu, Ms, Rat, Dog, R. Mk
Predict Reactivity Bov, Pig, Rb, Sheep
Species Does Not React With Chk, Gpig
Tested Application Conj, Dot, ELISA, FACS, ICC/IF, IHC-Fr, IHC-P, IP, WB
Host Mouse
Clonality Monoclonal
Clone 11-5B
Isotype IgG1
Target Name CNPase
Antigen Species Human
Immunogen Purified human 2’-3’-cyclic nucleotide 3’-phosphodiesterase (CNPase)
Conjugation Un-conjugated
Alternate Names CNPase; 2',3'-cyclic-nucleotide 3'-phosphodiesterase; CNP1; CNP; EC 3.1.4.37

Application Instructions

Application Suggestion
Tested Application Dilution
ConjAssay-dependent
DotAssay-dependent
ELISAAssay-dependent
FACSAssay-dependent
ICC/IFAssay-dependent
IHC-FrAssay-dependent
IHC-P1:400
IPAssay-dependent
WBAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Brain

Properties

Form Liquid
Purification Purified Antibody
Buffer 1X PBS and 0.1% Sodium azide
Preservative 0.1% Sodium azide
Concentration 0.2 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 1267 Human CNP

GeneID: 12799 Mouse CNP

GeneID: 25275 Rat CNP

Gene Symbol CNP
Gene Full Name 2',3'-cyclic nucleotide 3' phosphodiesterase
Function May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. [UniProt]
Research Area Controls and Markers antibody; Neuroscience antibody
Calculated MW 48 kDa

Clone References

Role of 2',3'-cyclic nucleotide 3'-phosphodiesterase in the renal 2',3'-cAMP-adenosine pathway.

Jackson EK et al.
Am J Physiol Renal Physiol.,  (2014)

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Fluorescence-activated sorting of fixed nuclei: a general method for studying nuclei from specific cell populations that preserves post-translational modifications.

FACS / Mouse

Marion-Poll L et al.
Eur J Neurosci.,  (2014)

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Multiple pathogenic proteins implicated in neuronopathic Gaucher disease mice.

Xu YH et al.
Hum Mol Genet.,  (2014)

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Prolonged myelination in human neocortical evolution.

WB / Human, Chimpanzee

Miller DJ et al.
Proc Natl Acad Sci U S A.,  (2012)

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Neuro-glial and systemic mechanisms of pathological responses in rat models of primary blast overpressure compared to composite blast.

IHC-P / Rat

Svetlov SI et al.
Front Neurol.,  (2012)

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SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis.

ICC/IF / Mouse

Luthi-Carter R et al.
Proc Natl Acad Sci U S A.,  (2010)

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Internalized somatostatin receptor subtype 2 in neuroendocrine tumors of octreotide-treated patients.

ICC/IF, IHC-P / Human

Reubi JC et al.
J Clin Endocrinol Metab.,  (2010)

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Axonal prion protein is required for peripheral myelin maintenance.

WB / Mouse

Bremer J et al.
Nat Neurosci.,  (2010)

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Protection of neurons from apoptosis by apolipoprotein E-containing lipoproteins does not require lipoprotein uptake and involves activation of phospholipase Cgamma1 and inhibition of calcineurin.

ICC/IF / Mouse, Rat

Hayashi H et al.
J Biol Chem.,  (2009)

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miR-23 regulation of lamin B1 is crucial for oligodendrocyte development and myelination.

WB, ICC/IF, IHC-FoFr / Mouse

Lin ST et al.
Dis Model Mech.,  (2009)

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