ARG63318

anti-COPS2 / TRIP15 antibody

anti-COPS2 / TRIP15 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse

Gene Regulation antibody; Signaling Transduction antibody

Overview

Product Description Goat Polyclonal antibody recognizes COPS2 / TRIP15
Tested Reactivity Hu, Ms
Predict Reactivity Cow, Rat, Dog
Tested Application IHC-P, WB
Host Goat
Clonality Polyclonal
Isotype IgG
Target Name COPS2 / TRIP15
Antigen Species Human
Immunogen C-LNSLNQAVVSKLA
Conjugation Un-conjugated
Alternate Names Alien homolog; Thyroid receptor-interacting protein 15; COP9 signalosome complex subunit 2; TR-interacting protein 15; SGN2; Signalosome subunit 2; JAB1-containing signalosome subunit 2; ALIEN; CSN2; TRIP-15; TRIP15

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P3 - 5 µg/ml
WB1 - 3 µg/ml
Application Note WB: Recommend incubate at RT for 1h.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Buffer Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA
Preservative 0.02% Sodium azide
Stabilizer 0.5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 12848 Mouse COPS2

GeneID: 9318 Human COPS2

Swiss-port # P61201 Human COP9 signalosome complex subunit 2

Swiss-port # P61202 Mouse COP9 signalosome complex subunit 2

Gene Symbol COPS2
Gene Full Name COP9 signalosome subunit 2
Function Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. [UniProt]
Research Area Gene Regulation antibody; Signaling Transduction antibody
Calculated MW 52 kDa
PTM Phosphorylated by CK2 and PKD kinases.