ARG56493
anti-COX1 antibody
anti-COX1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes COX1 |
|---|---|
| Tested Reactivity | Ms, Rat |
| Species Does Not React With | Hu, Sheep |
| Tested Application | IHC-P, WB |
| Specificity | This antibody does not react to COX-2. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | COX1 |
| Antigen Species | Mouse |
| Immunogen | Synthetic peptide around aa. 274-288 of Mouse COX-1. (LMRYPPGVPPERQMA) |
| Conjugation | Un-conjugated |
| Alternate Names | Prostaglandin H2 synthase 1; COX-1; PHS1; Cyclooxygenase-1; PGHS1; COX3; COX1; PGG/HS; PTGHS; PES-1; EC 1.14.99.1; PHS 1; Prostaglandin-endoperoxide synthase 1; PGHS-1; PCOX1; PGH synthase 1; Prostaglandin G/H synthase 1 |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | Ptgs1 |
| Gene Full Name | prostaglandin-endoperoxide synthase 1 |
| Background | This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| Function | Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. [UniProt] |
| Calculated MW | 69 kDa |
