ARG56542
anti-COX1 antibody [CX111] (FITC)
anti-COX1 antibody [CX111] (FITC) for Flow cytometry,ICC/IF and Human,Mouse,Rat,Bovine,Sheep
Overview
| Product Description | Mouse Monoclonal antibody [CX111] recognizes COX1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat, Bov, Sheep |
| Tested Application | FACS, ICC/IF |
| Specificity | This antibody may cross-react to COX-2 in following species: Sheep (50%), Human COX-2 (~5%) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | CX111 |
| Isotype | IgG2b |
| Target Name | COX1 |
| Antigen Species | Sheep |
| Immunogen | Purified Sheep COX-1. |
| Conjugation | FITC |
| Alternate Names | Prostaglandin H2 synthase 1; COX-1; PHS1; Cyclooxygenase-1; PGHS1; COX3; COX1; PGG/HS; PTGHS; PES-1; EC 1.14.99.1; PHS 1; Prostaglandin-endoperoxide synthase 1; PGHS-1; PCOX1; PGH synthase 1; Prostaglandin G/H synthase 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | PBS (pH 7.2), 0.02% Sodium azide, 50% Glycerol and 0.5 mg/ml BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol and 0.5 mg/ml BSA |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PTGS1 |
| Gene Full Name | prostaglandin-endoperoxide synthase 1 |
| Background | This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| Function | Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. [UniProt] |
| Calculated MW | 69 kDa |
