ARG59915
anti-CRCP antibody
anti-CRCP antibody for Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CRCP |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CRCP |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-115 of Human CRCP (NP_001035737.1). |
| Conjugation | Un-conjugated |
| Alternate Names | CGRPRCP; Calcitonin gene-related peptide-receptor component protein; RNA polymerase III subunit C9; RCP; RCP9; CGRP-receptor component protein; HsC17; CGRP-RCP; DNA-directed RNA polymerase III subunit RPC9 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Mouse testis and Jurkat | ||||
| Observed Size | 17 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O35427 Mouse DNA-directed RNA polymerase III subunit RPC9 Swiss-port # O75575 Human DNA-directed RNA polymerase III subunit RPC9 |
|---|---|
| Gene Symbol | CRCP |
| Gene Full Name | CGRP receptor component |
| Background | This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues. [UniProt] |
| Cellular Localization | Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. [UniProt] |
| Calculated MW | 17 kDa |
