ARG55434
anti-CREB3L4 / AIBZIP antibody
anti-CREB3L4 / AIBZIP antibody for Western blot and Human
Gene Regulation antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CREB3L4 / AIBZIP |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CREB3L4 / AIBZIP |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide corresponding to aa. 338-366 (C-terminus) of Human CREB3L4. |
| Conjugation | Un-conjugated |
| Alternate Names | Transcript induced in spermiogenesis protein 40; cAMP-responsive element-binding protein 3-like protein 4; Androgen-induced basic leucine zipper protein; Cyclic AMP-responsive element-binding protein 3-like protein 4; cAMP-responsive element-binding protein 4; CREB4; CREB3; hJAL; Tisp40; ATCE1; JAL; Cyclic AMP-responsive element-binding protein 4; Attaching to CRE-like 1; CREB-4; AIbZIP; AIBZIP |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | PC-3 |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A and immunogen peptide. |
| Buffer | PBS and 0.09% (W/V) Sodium azide |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8TEY5 Human Cyclic AMP-responsive element-binding protein 3-like protein 4 |
|---|---|
| Gene Symbol | CREB3L4 |
| Gene Full Name | cAMP responsive element binding protein 3-like 4 |
| Background | This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| Function | Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). [UniProt] |
| Cellular Localization | Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=May also be located in Golgi apparatus |
| Research Area | Gene Regulation antibody |
| Calculated MW | 43 kDa |
| PTM | N-glycosylated in the C-terminal region. Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity). |
