ARG55434

anti-CREB3L4 / AIBZIP antibody

anti-CREB3L4 / AIBZIP antibody for Western blot and Human

Gene Regulation antibody

Overview

Product Description Rabbit Polyclonal antibody recognizes CREB3L4 / AIBZIP
Tested Reactivity Hu
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name CREB3L4 / AIBZIP
Antigen Species Human
Immunogen KLH-conjugated synthetic peptide corresponding to aa. 338-366 (C-terminus) of Human CREB3L4.
Conjugation Un-conjugated
Alternate Names Transcript induced in spermiogenesis protein 40; cAMP-responsive element-binding protein 3-like protein 4; Androgen-induced basic leucine zipper protein; Cyclic AMP-responsive element-binding protein 3-like protein 4; cAMP-responsive element-binding protein 4; CREB4; CREB3; hJAL; Tisp40; ATCE1; JAL; Cyclic AMP-responsive element-binding protein 4; Attaching to CRE-like 1; CREB-4; AIbZIP; AIBZIP

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control PC-3

Properties

Form Liquid
Purification Purification with Protein A and immunogen peptide.
Buffer PBS and 0.09% (W/V) Sodium azide
Preservative 0.09% (W/V) Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 148327 Human CREB3L4

Swiss-port # Q8TEY5 Human Cyclic AMP-responsive element-binding protein 3-like protein 4

Gene Symbol CREB3L4
Gene Full Name cAMP responsive element binding protein 3-like 4
Background This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Function Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). [UniProt]
Cellular Localization Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=May also be located in Golgi apparatus
Research Area Gene Regulation antibody
Calculated MW 43 kDa
PTM N-glycosylated in the C-terminal region.
Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).