ARG43713
anti-CRH / Corticotropin Releasing Factor antibody
anti-CRH / Corticotropin Releasing Factor antibody for Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CRH / Corticotropin Releasing Factor |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CRH / Corticotropin Releasing Factor |
| Antigen Species | Human |
| Immunogen | Recombinant protein sequence corresponding to the a.a. 25-194 of Human CRF protein. |
| Conjugation Note | Un-conjugated |
| Protein Full Name | Corticoliberin |
| Alternate Names | CRH; Corticoliberin; Corticotropin-releasing hormone; CRF; CRH1; Corticotropin-releasing factor |
Application Instructions
| Application Suggestion |
|
||||
|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Observed Size | 25-30 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS (pH7.3), 0.02% Sodium azide and 50% Glycerol |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CRH |
| Gene Full Name | corticotropin releasing hormone |
| Background | Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Apr 2010] |
| Function | This hormone from hypothalamus regulates the release of corticotropin from pituitary gland. [UniProt] |
| Cellular Localization | Secreted. [UniProt] |
| Calculated MW | 21.4 kDa |
| PTM | Amidation, Cleavage on pair of basic residues |
