ARG54363
anti-CX3CR1 (extracellular loop) antibody
anti-CX3CR1 (extracellular loop) antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Cancer antibody; Controls and Markers antibody; Immune System antibody; Microbiology and Infectious Disease antibody; Neuroscience antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CX3CR1 (extracellular loop) |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, WB |
| Specificity | This antibody recognizes human, mouse and rat CX3CR1 (50 kD). |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CX3CR1 (extracellular loop) |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to aa. 175-189 of Human CX3CR1. |
| Conjugation | Un-conjugated |
| Alternate Names | CMK-BRL1; GPR13; CX3CR1; CMK-BRL-1; C-X3-C CKR-1; CX3C chemokine receptor 1; V28; CCRL1; GPRV28; CMKBRL1; G-protein coupled receptor 13; CMKDR1; Beta chemokine receptor-like 1; Fractalkine receptor |
Application Instructions
| Application Suggestion |
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| Application Note | Western blot: use at 1:500 dilution. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| Positive Control | THP-1 |
Properties
| Form | Liquid |
|---|---|
| Purification | Immunoaffinity chroma-tography |
| Buffer | PBS (pH 7.4) and 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
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| Gene Symbol | CX3CR1 |
| Gene Full Name | chemokine (C-X3-C motif) receptor 1 |
| Background | CX 3 CR1 is one of the chemokine receptors that are required as co-receptors for HIV infection. The genes encoding human, murine, and rat CX 3 CR1 have been cloned and designated V28 and CMKBRL1, CX 3 CR1, and RBS11, respectively. This transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and was renamed CX 3 CR1. Recently, CX 3 CR1was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by factalkine. CX 3 CR1 mediates leukocyte migration and adhesion and is expressed in a variety of human tissues and cell lines. |
| Function | Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1. [UniProt] |
| Research Area | Cancer antibody; Controls and Markers antibody; Immune System antibody; Microbiology and Infectious Disease antibody; Neuroscience antibody |
| Calculated MW | 40 kDa |
| PTM | This protein is not N-glycosylated which is unusual for G-protein-coupled receptors. |
