ARG56661

anti-CXCL2 / MIP2 antibody

anti-CXCL2 / MIP2 antibody for ELISA,Western blot,Neutralizing and Mouse,Rat

publication_link Publication1

Overview

Product Description Rabbit Polyclonal antibody recognizes CXCL2 / MIP2
Tested Reactivity Ms, Rat
Tested Application ELISA, Neut, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name CXCL2 / MIP2
Antigen Species Mouse
Immunogen E.coli derived Recombinant Mouse MIP-2 (CXCL2).
(AVVASELRCQ CLKTLPRVDF KNIQSLSVTP PGPHCAQTEV IATLKGGQKV CLDPEAPLVQ KIIQKILNKG KAN)
Conjugation Un-conjugated
Alternate Names Gro-beta; SCYB2; HSF; CINC-2a; GROb; MGSA-b; SB-251353; MIP2A; MIP2; Hematopoietic synergistic factor; 5-73; C-X-C motif chemokine 2; MIP-2a; GRO2; Macrophage inflammatory protein 2-alpha; GRO-beta-T; Growth-regulated protein beta; MIP2-alpha

Application Instructions

Application Suggestion
Tested Application Dilution
ELISASandwich: 0.5 - 2.0 µg/ml with ARG56771 as a detection antibody
Neut0.52 - 0.90 µg/ml (To yield [ND50] of the biological activity of mMIP - 2 (15.00 ng/ml) )
WB0.1 - 0.2 µg/ml
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS (pH 7.2)
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 114105 Rat CXCL2

GeneID: 20310 Mouse CXCL2

Swiss-port # P10889 Mouse C-X-C motif chemokine 2

Swiss-port # P30348 Rat C-X-C motif chemokine 2

Gene Symbol Cxcl2
Gene Full Name chemokine (C-X-C motif) ligand 2
Background This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]
Function Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. [UniProt]
Calculated MW 11 kDa
PTM The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.

Specific References

Self-recruited neutrophils trigger over-activated innate immune response and phenotypic change of cardiomyocytes in fulminant viral myocarditis

Neut / Mouse

Huihui Li et al.
Cell discovery,  (2023)

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