ARG11053

anti-CXCR1 antibody

anti-CXCR1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human

Overview

Product Description Rabbit Polyclonal antibody recognizes CXCR1
Tested Reactivity Hu
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name CXCR1
Antigen Species Human
Immunogen Synthetic peptide around the N-terminus of Human CXCR1. (DEDYSPCMLETETLN)
Conjugation Un-conjugated
Alternate Names IL8RBA; C-C-CKR-1; IL-8R A; CKR-1; High affinity interleukin-8 receptor A; IL8RA; C-C; CD128; CD antigen CD181; CDw128a; CXCR-1; CXC-R1; IL-8 receptor type 1; CD181; IL8R1; CMKAR1; C-X-C chemokine receptor type 1

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1 - 5 µg/ml
WB0.5 - 1 µg/ml
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Observed Size ~ 40 kDa

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS, 0.025% Sodium azide and 2.5% BSA.
Preservative 0.025% Sodium azide
Stabilizer 2.5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 3577 Human CXCR1

Swiss-port # P25024 Human C-X-C chemokine receptor type 1

Gene Symbol CXCR1
Gene Full Name chemokine (C-X-C motif) receptor 1
Background The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]
Function Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. [UniProt]
Calculated MW 40 kDa