ARG57512

Name: anti-Caspase 3 (cleaved) antibody
Brand: arigo Biolaboratories
SKU: ARG57512
Price: 345 USD
Availability: InStock
Rating: 5.0 (2 reviews)

anti-Caspase 3 (cleaved) antibody

Publication2

Ordering Information

Package

Price (USD)

100 μl

345.00

50 μl

245.00

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Overview

Product Description	Rabbit Polyclonal antibody recognizes Caspase 3 (cleaved)
Tested Reactivity	Hu
Predict Reactivity	Ms, Rat, Bov, Pig
Tested Application	IHC-P, WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	Caspase 3 (cleaved)
Antigen Species	Human
Immunogen	KLH-conjugated synthetic peptide corresponding to aa. 149-175 of Human Caspase 3.
Conjugation	Un-conjugated
Alternate Names	CPP-32; Caspase-3; EC 3.4.22.56; Apopain; CASP-3; CPP32; Cysteine protease CPP32; SCA-1; SREBP cleavage activity 1; CPP32B; Protein Yama

Application Instructions

Application Suggestion

Tested Application	Dilution
IHC-P	1:50 - 1:100
WB	1:500

Application Note

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form	Liquid
Purification	Purification with Protein A and immunogen peptide.
Buffer	PBS and 0.09% (W/V) Sodium azide.
Preservative	0.09% (W/V) Sodium azide.
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 836 Human CASP3 Swiss-port # P42574 Human Caspase-3
Gene Symbol	CASP3
Gene Full Name	caspase 3, apoptosis-related cysteine peptidase
Background	This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. [UniProt]
Cellular Localization	Cytoplasm
Research Area	Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Neuroscience antibody; Apoptosis Marker antibody; Mitochondria/Caspase Dependant Apoptosis Marker antibody
Calculated MW	17 kDa (cleaved)