ARG55171
anti-Caspase 5 antibody
anti-Caspase 5 antibody for ELISA,ICC/IF,Western blot and Human
Cell Biology and Cellular Response antibody; Cell Death antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Caspase 5 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA, ICC/IF, WB |
| Specificity | Depending on cell lines or tissues used, other cleavage products may be observed. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Caspase 5 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide (14 aa) within aa. 170-220 of Human Caspase-5. |
| Conjugation | Un-conjugated |
| Alternate Names | Protease ICH-3; Caspase-5; Protease TY; CASP-5; EC 3.4.22.58; ICE; ICEREL-III; ICH-3; ICE(rel)III; rel |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | Ramos Cell Lysate |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS and 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CASP5 |
| Gene Full Name | caspase 5, apoptosis-related cysteine peptidase |
| Background | Caspase-5 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1β and IL-18. Caspase-5 can interact with caspase-1; both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1β. Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-gamma. | |
| Function | Mediator of programmed cell death (apoptosis). |
| Research Area | Cell Biology and Cellular Response antibody; Cell Death antibody |
| Calculated MW | 50 kDa |
| PTM | The two subunits are derived from the precursor sequence by an autocatalytic mechanism. |
