ARG42664
anti-Cathepsin L + Cathepsin V + Cathepsin K + Cathepsin H antibody
anti-Cathepsin L + Cathepsin V + Cathepsin K + Cathepsin H antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections,ICC/IF,Flow cytometry and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Cathepsin L + Cathepsin V + Cathepsin K + Cathepsin H |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Cathepsin L + Cathepsin V + Cathepsin K + Cathepsin H |
| Antigen Species | Human |
| Immunogen | Synthetic peptide derived from Human Cathepsin L+V+K+H. |
| Conjugation | Un-conjugated |
| Alternate Names | Major excreted protein; Cathepsin L; CATL; Cathepsin L1; EC 3.4.22.15; CTSL1; MEP |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| Positive Control | HepG2 | ||||||||||
| Observed Size | ~ 39 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CTSL |
| Gene Full Name | cathepsin L |
| Background | The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012] |
| Function | Important for the overall degradation of proteins in lysosomes. [UniProt] |
| Cellular Localization | Lysosome. [UniProt] |
| Calculated MW | CTSL: 38 kDa CTSV: 37 kDa CTSK: 37 kDa CTSH: 37 kDa |
