ARG40174

anti-Cathepsin S antibody

anti-Cathepsin S antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human

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Overview

Product Description Rabbit Polyclonal antibody recognizes Cathepsin S
Tested Reactivity Hu
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name Cathepsin S
Antigen Species Human
Immunogen Synthetic peptide derived from Human Cathepsin S.
Conjugation Un-conjugated
Alternate Names Cathepsin S; EC 3.4.22.27

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:50 - 1:200
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control U-87MG
Observed Size 25 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 1520 Human CTSS

Swiss-port # P25774 Human Cathepsin S

Gene Symbol CTSS
Gene Full Name cathepsin S
Background The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Function Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. [UniProt]
Cellular Localization Lysosome. [UniProt]
Calculated MW 37 kDa

Specific References

Physiological β-amyloid clearance by the liver and its therapeutic potential for Alzheimer’s disease

WB / Human

Yuan Cheng et al.
Acta Neuropathol.,  (2023)

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Amyloid-beta uptake by blood monocytes is reduced with ageing and Alzheimer's disease.

WB / Human

Si-Han Chen et al.
Transl Psychiatry.,  (2020)

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