ARG52245

anti-Clavesin antibody

anti-Clavesin antibody for Western blot,ICC/IF and Rat

Cancer antibody; Signaling Transduction antibody

Overview

Product Description Rabbit Polyclonal antibody recognizes Clavesin
Tested Reactivity Rat
Predict Reactivity Hu, Ms
Tested Application ICC/IF, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name Clavesin
Antigen Species Rat
Immunogen Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH
Conjugation Un-conjugated
Alternate Names Clavesin-1; Retinaldehyde-binding protein 1-like 1; Cellular retinaldehyde-binding protein-like; CRALBPL; RLBP1L1

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IF1:50
WB1:1,000
Application Note Specific for the ~ 35 kDa clavesin 1/2 protein doublet in Western blots of Rat brain lysate. Isoform-specific knock down in cultured hippocampal neurons indicates that the lower and upper bands are clavesin 1 and 2, respectively.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity Purified
Buffer PBS and 50% Glycerol
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 366311 Rat CLVS1

Swiss-port # A6JFQ6 Rat Clavesin-1

Gene Symbol CLVS1/2
Gene Full Name clavesin 1
Background Clavesin (clathrin vesicle associated Sec14 protein) is a novel neuron specific protein that has recently been identified and shown to be required for normal morphology of late endosomes and/or lysosomes as lentiviral-mediated knockdown of clavesin in hippocampal neurons causes lysosomal defects (Katoh et al., 2009). Additionally, upregulation of clavesin in human hepatocellular carcinoma has recently been demonstrated thus making it a useful marker for this disease state (Zhao et al., 2008).
Research Area Cancer antibody; Signaling Transduction antibody
Calculated MW 41 kDa