ARG57338

anti-Collagen I alpha 2 antibody

anti-Collagen I alpha 2 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Mouse

Overview

Product Description Rabbit Polyclonal antibody recognizes Collagen I alpha 2
Tested Reactivity Ms
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name Collagen I alpha 2
Antigen Species Human
Immunogen Recombinant Protein of Human COL1A2.
Conjugation Un-conjugated
Alternate Names OI4; Collagen alpha-2(I) chain; Alpha-2 type I collagen

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-PAssay-dependent
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Mouse kidney

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 12843 Mouse COL1A2

Swiss-port # Q01149 Mouse Collagen alpha-2(I) chain

Gene Symbol COL1A2
Gene Full Name collagen, type I, alpha 2
Background This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
Function Type I collagen is a member of group I collagen (fibrillar forming collagen). [UniProt]
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Calculated MW 129 kDa
PTM Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.