ARG64231
anti-Collagen VII antibody
anti-Collagen VII antibody for Western blot and Rat
Signaling Transduction antibody
Overview
| Product Description | Goat Polyclonal antibody recognizes Collagen VII |
|---|---|
| Tested Reactivity | Rat |
| Predict Reactivity | Hu, Ms, Dog, Pig |
| Tested Application | WB |
| Specificity | This product does not work on cryostat sections of Normal Human Skin. |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Collagen VII |
| Antigen Species | Human |
| Immunogen | C-TVQYSDDPRTEF |
| Conjugation | Un-conjugated |
| Alternate Names | LC collagen; EBR1; VII; EBDCT; NDNC8; Collagen alpha-1; Long-chain collagen; EBD1 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Background | This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. [provided by RefSeq, Jul 2008] |
|---|---|
| Research Area | Signaling Transduction antibody |
| Calculated MW | 295 kDa |
| PTM | Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. |
