ARG23074
anti-Collagen VII antibody [LH7.2]
anti-Collagen VII antibody [LH7.2] for IHC-Frozen sections and Human
Overview
| Product Description | Mouse Monoclonal antibody [LH7.2] recognizes Collagen VII |
|---|---|
| Tested Reactivity | Hu |
| Species Does Not React With | Ms, Rat, Pig |
| Tested Application | IHC-Fr |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | LH7.2 |
| Isotype | IgG1 |
| Target Name | Collagen VII |
| Antigen Species | Human |
| Immunogen | Crude extract of skin |
| Conjugation | Un-conjugated |
| Alternate Names | EBD1; EBR1; EBDCT; NDNC8; Collagen alpha-1(VII) chain; Long-chain collagen; LC collagen |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS and 0.09% Sodium azide |
| Preservative | 0.09% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | COL7A1 |
| Gene Full Name | collagen, type VII, alpha 1 |
| Background | This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. [provided by RefSeq, Jul 2008] |
| Function | Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. [UniProt] |
| Calculated MW | 295 kDa |
| PTM | Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. |
