ARG23546

anti-Complement C6 antibody [056B-214.2.4.2]

anti-Complement C6 antibody [056B-214.2.4.2] for IHC-Frozen sections,ELISA,Flow cytometry and Human

Overview

Product Description Mouse Monoclonal antibody [056B-214.2.4.2] recognizes Complement C6.
Mouse anti Human C6 antibody, clone 056B-214.2.4.2 recognizes complement component 6 (C6), a 104 kDa member of the complement C6/C7/C8/C9 family present in blood serum. The factor I modules of C6 bind the C-terminus of the C5b alpha-chain, anchoring the molecule to the membrane; they also binds complement component 7. This enables the formation of the C5b-€“7 precursor complex. C5b-€“7 then functions as a receptor for components C8 and C9 which form the complement membrane attack complex (MAC). Deficiency of C6 results in susceptibility to bacterial infection.Mouse anti Human C6 antibody, clone 056B-214.2.4.2 recognizes MAC.
Tested Reactivity Hu
Tested Application ELISA, FACS, IHC-Fr
Host Mouse
Clonality Monoclonal
Clone 056B-214.2.4.2
Isotype IgG1
Target Name Complement C6
Antigen Species Human
Immunogen Purified Human Complement C6.
Conjugation Un-conjugated
Alternate Names Complement component C6

Application Instructions

Application Suggestion
Tested Application Dilution
ELISAAssay-dependent
FACSAssay-dependent
IHC-FrAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purification with Protein A.
Buffer BBS and 0.1% Sodium azide.
Preservative 0.1% Sodium azide
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 729 Human C6

Swiss-port # P13671 Human Complement component C6

Gene Symbol C6
Gene Full Name complement component 6
Background This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012]
Function Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. [UniProt]
Calculated MW 105 kDa
PTM All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module. [UniProt]