ARG44275
anti-CtIP (Thr847) antibody
anti-CtIP (Thr847) antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CtIP phospho (Thr847) |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms, Bov, Chk, Dog, Goat, Gpig, Sheep |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CtIP |
| Antigen Species | Human |
| Immunogen | Synthetic phospho-peptide |
| Conjugation | Un-conjugated |
| Alternate Names | RBBP8; RB Binding Protein 8, Endonuclease; RIM; COM1; CTIP; Sporulation In The Absence Of SPO11 Protein 2 Homolog; Retinoblastoma-Binding Protein 8; Retinoblastoma Binding Protein 8; CTBP-Interacting Protein; DNA Endonuclease RBBP8; RBBP-8; SCKL2; CtIP; SAE2; Retinoblastoma-Interacting Protein And Myosin-Like; CtBP-Interacting Protein; Seckel Syndrome 2; EC 3.1.-.- ; JAWAD; JWDS |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Antigen Affinity Purified |
| Buffer | 10 mM HEPES (pH 7.5), 150 mM NaCl, 50% Glycerol and 100 µg/ml BSA. |
| Stabilizer | 50% Glycerol and 100 µg/ml BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | RBBP8 |
| Gene Full Name | RB Binding Protein 8, Endonuclease |
| Background | The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. |
| Function | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. |
| Cellular Localization | Chromosome, Nucleus |
| Calculated MW | 102 kDa |
| PTM | Isopeptide bond, Phosphoprotein, Ubl conjugation |
